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Important Safety Information

Do not use ZOMIG if you have:
  • heart problems, a history of heart problems, or problems with the electrical system of your heart
  • had a stroke, transient ischemic attacks (TIAs), or problems with your blood circulation
  • hemiplegic migraines or basilar migraines. If you are not sure if you have these types of migraines, ask your healthcare provider
  • narrowing of blood vessels to your legs, arms, or stomach (peripheral vascular disease)
  • uncontrolled high blood pressure
  • used other migraine medications in the last 24 hours, including other triptans, ergots, or ergot-type medications
  • used monoamine oxidase (MAO) inhibitors for depression or other conditions within the last 14 days
  • allergies to zolmitriptan or any of the ingredients in ZOMIG, ZOMIG-ZMT or ZOMIG Nasal Spray

If you are not sure about any of the above, ask your doctor.

  • Before taking ZOMIG, tell your doctor about all your medical conditions, including if you have high blood pressure, high cholesterol, diabetes, if you smoke, are overweight, are a female who has gone through menopause, have heart disease or a family history of heart disease or stroke, have liver problems, are pregnant or plan to become pregnant, are breastfeeding or plan to breastfeed.
  • Tell your doctor about all the medicines you take, including prescription and over-the-counter medicines, vitamins, and herbal supplements. Especially tell your doctor if you take medicines used to treat mood disorders including selective serotonin reuptake inhibitors (SSRIs), serotonin norepinephrine reuptake inhibitors (SNRIs), monoamine oxidase (MAO) inhibitors or cimetidine (reduces stomach acid production).
  • ZOMIG can cause serious side effects. Seek emergency help right away if you have any of the following symptoms of a heart attack such as: severe tightness, pain, pressure, or heaviness in your chest, throat, neck, or jaw that is severe or does not go away; shortness of breath or wheezing; or symptoms of a stroke such as: slurring of speech; or unusual weakness or numbness. Call your doctor right away if you have any of the following problems after taking ZOMIG: changes in color or sensation in your fingers and toes; sudden or severe stomach pain; cramping or pain in your legs or hips; bloody diarrhea; hives; tongue, mouth, lip or throat swelling; problems seeing. ZOMIG can cause heart attacks, increases in blood pressure, stroke, life-threatening disturbances of heart rhythm, constriction of blood vessels in the abdomen or other parts of the body, or serious allergic reactions. In extremely rare cases, patients have died from these side effects.
  • Some people who take ZOMIG may have a reaction called serotonin syndrome which can be life-threatening. In particular this reaction may occur when ZOMIG is used together with certain types of antidepressants known as SSRIs or SNRIs. Symptoms may include mental changes (confusion, seeing things that are not there (hallucinations), agitation, coma), fast heartbeat, changes in blood pressure, feeling faint, fever, sweating, muscle spasm, trouble walking, nausea, vomiting, and/or diarrhea. Call your doctor immediately if you have any of these symptoms after taking ZOMIG
  • Tell your doctor if you are sensitive to phenylalanine, which can be found in the artificial sweetener aspartame. ZOMIG-ZMT contains phenylalanine
  • The safety and effectiveness of ZOMIG have not been established in patients under 18 years of age or patients over 65 years of age
  • The most common side effects reported by patients in clinical trials for ZOMIG Tablets and ZOMIG-ZMT Orally Disintegrating Tablets include tingling sensation; weakness; nausea; dizziness; pain, tightness, pressure or heaviness such as in the chest, throat, neck, or jaw; drowsiness; and warm sensation. The most common side effects reported by patients in clinical studies for ZOMIG Nasal Spray include unusual taste; tingling sensation; skin sensitivity; dizziness; nausea; pain, pressure, and tightness sensations such as in the nose, throat, or chest; drowsiness; weakness; disorder/discomfort of the nasal cavity; and dry mouth

Approved Use for ZOMIG

ZOMIG is a prescription medicine approved to treat migraine headaches in adults. Only your doctor can determine if ZOMIG is right for you.

ZOMIG should only be used where a clear diagnosis of migraine has been established. For a given migraine attack, if you do not respond to the first dose of ZOMIG, then your doctor will need to determine if you really have a migraine headache before you take a second dose. ZOMIG is not for the prevention of migraines or for the treatment of hemiplegic or basilar migraines (if you are not sure about this, ask your doctor). ZOMIG is not for other types of headaches, including cluster headache.


This is not a complete summary of safety information. Please discuss the full Prescribing Information with your doctor.

You are encouraged to report negative side effects of prescription drugs to the FDA. Visit www.FDA.gov/medwatch, or call 1-800-FDA-1088.

Click here to see the full Prescribing Information for ZOMIG Nasal Spray.
Click here to see the full Prescribing Information for ZOMIG Tablets and ZOMIG-ZMT Orally Disintegrating Tablets.
Visit www.ZOMIG.com

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